- ISLA (Josh Rouse)
- Isla de Caras
- Isla de los Estados
- Isla Invisible
- Isla Mujeres (female indie electronic band from Argentina)
- Isla Noir
- Isla San Juan
- Isla, Connie
- Isla, Rae
- Islaja
- Islam, Rupam
- Islam, Yusuf (formerly Cat Stevens)
- Islam, Yusuf / Stevens, Cat
- Islam, Yusuf feat. Ben Ammi
- Islamia School Kids (UK)
- Islamović, Alen
- ISLAND (from London)
- Island (Wannes Van De Velde; Paul Rans; Dirk Van Esbroeck; ... (et al.))
- Island Apollo
- Island Caribbean Steel Drum Band
- Island Choral Experience
- Island Inspirational All-Stars, The
- Island Moons
- Island, Five Mile
- Island, Josh (Dutch musician)
- Islander (Rock Band)
- Islander feat. H.R.
- Islander feat. Sandoval, Sonny
- Islandia Nunca Quema
- Islandica
- Islandis (Sydney Indie-Pop Duo.)
- islandman
- Islands (indie rock band from Montreal, Canada)
- Islands (post-metal band from Sydney, Australia)
- ISLE (Scottish Band)
- isle & fever
- Isle of Avalon
- Isle Of CC, The
- Isle of Q
- Íslensku dívurnar
- Isles (US/ San Francisco heavy rock band)
- Isles & Glaciers
- Isles Of Goto (Polish art rock/shoegaze group)
- Isles, Keil, The
- Isles, The
- Islet (Cardiff no-wave band)
- Isley Brothers, The
- Isley Brothers, The feat. Beyoncé
- Isley Brothers, The feat. Isley, Ronald
- Isley Brothers, The feat. Isley, Ronald and Winbush, Angela
- Isley Brothers, The feat. JS
- Isley Brothers, The feat. Lil’ Kim
- Isley Brothers, The feat. Pied Piper, The
- Isley Brothers, The feat. Scott, Jill
- Isley Jasper Isley
- Isley, Alex
- Isley, Alex & Dine, Jack
- Isley, Melinda
- Isley, Ronald (a.k.a. Mr. Biggs)
- Isley, Ronald feat. Franklin, Aretha
- Isley, Ronald feat. Trey Songz
- Isleym
- Isma‐Ae, Jerome & Alastor feat. London Thor
- Isma‐Ae, Jerome with Cosmic Gate
- Ismael Ayende (Colombian Latin alternative band)
- Ismael, Claudio (Kizomba artist)
- Ismag, Tim
- Ismail Bilici
- İsmail YK
- Ismail, Saalim (Singer-songwriter)
- Ismajli, Adelina
- Ismen (Swedish hip hop)
- Ismeros Arcok
- Ismo Alanko Säätiö
- Ismo Alanko Teholla (Ismo Alanko and Teho Majamäki's project.)
- Ismo, Lijpe x
- Isn't It Always?
- Iso H
- ISO Indies
- Iso, King (Tarrel C. Gulledge)
- Iso, King feat. Daylyt
- Iso, King feat. King Kash & Snake Lucci
- Iso, King feat. Rittz & Twista
- Iso, King feat. Taebo tha Truth
- Isocel
- Isoir, André (organist)
- Isola (Belgian indie pop/rock band)
- Isolate.exe (phonk music)
- Isolated (~Johannes Gräf & Marcel Güntner)
- Isolated Corners